An Oregon woman suffered from rare blood clots, after receiving Johnson & Johnson’s CCP Virus (COVID-19) vaccine earlier this month. German scientists claim they hold the keys to the problem and how to solve it.
Barbara Buchanan chose Johnson & Johnson vaccine since it was a one-dose shot and specialists certified the vaccination safe after a 10-day hold was lifted, KGW8 reported. The Centers for Disease Control and Prevention (CDC) investigation into allegations of blood clots triggered the pause in the U.S.
Buchanan now says she regrets her choice. Six to eight days after her shot, the 63-year-old began to experience the symptoms, Children’s Health Defense reported.
“I had a low-grade temperature and I just felt really tired,” she said. “I thought I was suffering from seasonal allergies.”
Buchanan also experienced acute leg cramps, which she attributed to arthritis. She then began coughing up blood. A CT scan performed at Providence St. Vincent Medical Center revealed blood clots in her lungs, stomach, brain, and throat.
“There has been an association with a very small number of people getting this vaccine that can get this special kind of blood clot with low platelets,” said Dr. Ray Moreno, chief medical officer at St. Vincent.
Moreno said Buchanan had blood clots with low platelets, a pattern seen in cases that caused the CDC and the U.S. Food and Drug Administration to halt the immunization last month. However, Moreno claimed that the reaction is “very rare” and that people need not be afraid to acquire the vaccine.
“As with any medication or medical treatment, there is always the possibility of someone having an adverse reaction. That’s why it’s important to talk to your doctor, do your research and make an informed decision,” Moreno stated in a statement to ABC affiliate KAT2TV.
Buchanan described the event as “devastating.” She said she was “very scared that I was never going to see my home again or my family.” She stayed in the hospital for approximately a week before being released on May 24. Her clots are still present, and she will require blood thinners.
“I have a good support system at home, but I’m scared, I’m scared,” Buchanan said. “People don’t think when they go to bed at night that they’re not going to wake up the next day, I don’t know that anymore.”
German scientists say they know how to solve it
A group of German scientists believes they have figured out why some patients who receive the CCP Virus vaccines from AstraZeneca and Johnson & Johnson get blood clots, and they claim they can advise the producers how to alter the vaccination to avoid this, the Guardian reported.
According to Rolf Marschalek, a professor at Goethe University in Frankfurt, and colleagues, the secret is in the adenovirus, a common cold virus that is employed to carry the coronavirus’ spike protein into the body. Pfizer/BioNTech and Moderna’s mRNA vaccines do not use this delivery mechanism, and no incidents of blood clotting have been related to them.
Blood clots are uncommon, but they are concerning in the younger age group, which is more prone to clotting and less likely to develop severe CCP Virus sickness. In the UK, everyone under the age of 40 can now choose among a variety of immunizations if they are available. In the UK, 309 cases have been reported out of 33 million people who received the AstraZeneca vaccine.
The researchers believe the problem is caused by the adenovirus entering the nucleus of the cell rather than the cellular fluid, where the virus normally creates proteins, according to a pre-print that has not been peer reviewed.
“The adenovirus life cycle includes the infection of cells … entry of the adenoviral DNA into the nucleus, and subsequently gene transcription by the host transcription machinery,” they wrote.
“And exactly here lies the problem: the viral piece of DNA … is not optimised to be transcribed inside of the nucleus.”
Parts of the spike protein splice or split apart inside the cell nucleus. The scientists believe that these become mutant protein fragments that float around in the body and can occasionally cause blood clots.
The vaccines, according to Prof. Marschalek, can be altered to avoid the problem. He told the Financial Times that Johnson & Johnson has already contacted him. He told the newspaper that the corporation is currently “trying to optimise its vaccine now.”
“We can inform the firms how to alter these sequences, coding for the spike protein in a way that prevents unwanted splice reactions, using the data we have,” he said.
However, Marschalek stated that they had not yet spoken with AstraZeneca. He told the Times that the firm had not contacted him, but that if they did, he could advise them on how to improve the vaccine.
Other scientists, meanwhile, have different views, and Marschalek’s explanation of the bad outcomes is still a hypothesis that has to be tested by other experts.
According to the most recent data from the CDC’s Vaccine Adverse Events Reporting System (VAERS), there were 4,433 reports of clotting disorders and other associated diseases between December 14, 2020 and May 21, 2021. Pfizer received 1,842 reports, Moderna received 1,168 reports, and Johnson & Johnson received 1,093 reports.