Gary Sánchez hit his first career grand slam in a five-run fifth inning for his first hit following nearly two weeks on the injured list, and the New York Yankees beat the San Francisco Giants 6-4 on Saturday for their 10th win in 12 games.

Sánchez had been 0 for 9 with seven strikeouts since returning Wednesday from a strained left calf. His batting average down to .220, he crushed a high sinker from Derek Holland (1-4). The ball left the bat 111 mph and traveled 467 feet deep into the left-field seats for a 6-0 lead. He has seven home runs and 15 RBIs.

J.A. Happ (1-2) had his best outing this season, allowing five hits in seven scoreless innings, mixing 37 changeups with 38 fastballs among 95 pitches. He ended a streak of seven straight starts in which he allowed a home run.

New York Yankees' Gary Sanchez swings for a grand slam off San Francisco Giants' Derek Holland in the fifth inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)
New York Yankees’ Gary Sanchez swings for a grand slam off San Francisco Giants’ Derek Holland in the fifth inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)

New York, despite 13 players on the injured list, improved to 5-1 on a nine-game trip and at 16-11 moved a season-high five games over .500.

Gio Urshela doubled twice and had three hist, and Cameron Maybin singled and scored in his second game with the Yankees. Luke Voit was hit by a pitch to extend his on-base streak to 38 games for the Yankees, the longest active streak in the majors.

San Francisco, which has lost six of nine, was shut out until the ninth, when Yangervis Solarte hit a three-run homer off Luis Cessa and Erik Kratz hit a solo drive. Aroldis Chapman struck out Pablo Sandoval on a checked swing for his fifth save in six chances.

New York Yankees' Gary Sanchez swings for a grand slam off San Francisco Giants' Derek Holland in the fifth inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)
New York Yankees’ Gary Sanchez swings for a grand slam off San Francisco Giants’ Derek Holland in the fifth inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)

Holland dropped to 1-8 against the Yankees, giving up six runs, six hits and three walks in five innings.

DJ LeMahieu hit an RBI single in the third, and Voit was nicked on the right knee by a pitch with the bases loaded in the fifth.

TRAINER’S ROOM

New York Yankees' Gary Sanchez, right, celebrates with Luke Voit (45) after hitting a grand slam off San Francisco Giants' Derek Holland in the fifth inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)
New York Yankees’ Gary Sanchez, right, celebrates with Luke Voit (45) after hitting a grand slam off San Francisco Giants’ Derek Holland in the fifth inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)

Yankees: OF Clint Frazier (left ankle sprain) played catch on the field before the game. Manager Aaron Boone thinks Frazier could return within two weeks. … CF Aaron Hicks (back strain) could take face pitching next week. … Miguel Andújar (torn labrum in right shoulder) went 3 for 3 as a designated hitter in extended spring training. Andújar will have Sunday off then play third base in another extended spring training game Monday.

Giants: OF Steven Duggar was held out of the lineup after injuring his right wrist stumbling over the bullpen mound near right field a day earlier.

UP NEXT

New York Yankees pitcher Aroldis Chapman, right, celebrates the 6-4 win over the San Francisco Giants with catcher Gary Sanchez (24) at the end of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)
New York Yankees pitcher Aroldis Chapman, right, celebrates the 6-4 win over the San Francisco Giants with catcher Gary Sanchez (24) at the end of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)

Yankees RHP Domingo Germán (4-1, 1.75 ERA) faces the Giants for the first time in his career in the series finale Sunday. Germán already has more wins than he did over the previous two seasons combined. LHP Dereck Rodriguez (3-2) pitches for San Francisco in his second interleague start.

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New York Yankees pitcher J.A. Happ works against the San Francisco Giants in the first inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)
New York Yankees pitcher J.A. Happ works against the San Francisco Giants in the first inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)
New York Yankees pitcher J.A. Happ works against the San Francisco Giants in the first inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)
New York Yankees pitcher J.A. Happ works against the San Francisco Giants in the first inning of a baseball game Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)
San Francisco Giants' Yangervis Solarte celebrates after hitting a three-run home run against the New York Yankees in the ninth inning of a baseball game, Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)
San Francisco Giants’ Yangervis Solarte celebrates after hitting a three-run home run against the New York Yankees in the ninth inning of a baseball game, Saturday, April 27, 2019, in San Francisco. (AP Photo/Ben Margot)

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