Luis Castillo matched a season high with nine strikeouts and Jesse Winker added a pinch-hit homer as the Cincinnati Reds beat San Diego 4-2 Saturday and extended the Padres’ losing streak to six games.

The Reds won their third straight after arriving in San Diego mired in a four-game losing streak.

Castillo (2-1) pitched six innings and was charged with one run, four hits and a walk. After Eric Hosmer (three hits, two RBIs) homered in the second inning, and only one other Padres player reached scoring position.

Cincinnati Reds' Jesse Winker, left, celebrates in a leap with Jose Iglesias, right, after hitting a solo home run as Yasiel Puig, center, watches, during the seventh inning of a baseball game against the San Diego Padres in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
Cincinnati Reds’ Jesse Winker, left, celebrates in a leap with Jose Iglesias, right, after hitting a solo home run as Yasiel Puig, center, watches, during the seventh inning of a baseball game against the San Diego Padres in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)

Raisel Iglesias got the last three outs for his fourth save.

Rookie Fernando Tatis Jr. had his first career triple to lead off the eighth inning, extending his hitting streak to nine games. Manny Machado walked and Hosmer drove in Tatis, cutting the deficit to 4-2. Wil Myers grounded out to end the inning.

Eric Lauer (2-3) pitched five innings, giving up three runs and six hits, with two walks. Lauer struck out five and lost for the third time in four starts.

San Diego Padres right fielder Hunter Renfroe leaps but cannot reach a solo home run hit by Cincinnati Reds' Jesse Winker during the seventh inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
San Diego Padres right fielder Hunter Renfroe leaps but cannot reach a solo home run hit by Cincinnati Reds’ Jesse Winker during the seventh inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)

Winker’s fourth career pinch-hit homer in the seventh inning gave the Reds a 4-1 lead. Winker leads the Reds with six home runs.

Lauer led the majors last season with 10 pickoffs. But when he tried to catch Eugenio Suarez, who walked to start the fifth inning, his erratic throw produced a two-base error. Yasiel Puig then drove in Suarez with a sacrifice fly for 3-1 advantage.

In the fourth inning, Scott Schebler and Kyle Farmer reached on hits and Tucker Barnhart had an RBI single to give the Reds as 2-1 lead.

Cincinnati Reds' Jesse Winker, right, follows through to hit a solo home run with San Diego Padres catcher Francisco Mejia watching during the seventh inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
Cincinnati Reds’ Jesse Winker, right, follows through to hit a solo home run with San Diego Padres catcher Francisco Mejia watching during the seventh inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)

Hosmer tied the game at 1 in the second with his second homer of the season.

The Reds struck in the first when Jose Peraza, who batted leadoff for the first time and ended a career-worst 0-for-24 streak with a single, scored on a single by Jose Iglesias.

TRAINER’S ROOM

Cincinnati Reds' Yasiel Puig hits an RBI-sacrifice fly to score Francisco Mejia against the San Diego Padres during the fifth inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
Cincinnati Reds’ Yasiel Puig hits an RBI-sacrifice fly to score Francisco Mejia against the San Diego Padres during the fifth inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)

Reds: 1B Joey Votto (back) was out of the lineup, but expected to play in Sunday’s series finale.

UP NEXT

Reds: RHP Tyler Mahle (0-1, 2.65), who’s been among the top rookie pitchers this season, is scheduled to make his fourth start.

San Diego Padres' Eric Hosmer, second from right, celebrates with Manny Machado, left, and Franmil Reyes, right, after hitting a solo home run against the Cincinnati Reds during the second inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
San Diego Padres’ Eric Hosmer, second from right, celebrates with Manny Machado, left, and Franmil Reyes, right, after hitting a solo home run against the Cincinnati Reds during the second inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)

Padres: LHP Joey Lucchesi (2-2, 4.40) is expected to start. He is looking to snap a two-game losing streak.

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Cincinnati Reds' Eugenio Suarez, right, beats the throw to San Diego Padres catcher Francisco Mejia, left, to score on a sacrifice fly hit by Yasiel Puig during the fifth inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
Cincinnati Reds’ Eugenio Suarez, right, beats the throw to San Diego Padres catcher Francisco Mejia, left, to score on a sacrifice fly hit by Yasiel Puig during the fifth inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
San Diego Padres' Eric Hosmer reacts after returning to the plate after hitting a solo home run against the Cincinnati Reds during the second inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
San Diego Padres’ Eric Hosmer reacts after returning to the plate after hitting a solo home run against the Cincinnati Reds during the second inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
San Diego Padres' Eric Hosmer, right, celebrates with Franmil Reyes, left, after hitting a solo home run against the Cincinnati Reds during the second inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)
San Diego Padres’ Eric Hosmer, right, celebrates with Franmil Reyes, left, after hitting a solo home run against the Cincinnati Reds during the second inning of a baseball game in San Diego, Saturday, April 20, 2019. (AP Photo/Alex Gallardo)