Adam Plutko, making his first appearance of the season, allowed one run in six innings— a solo homer by Trey Mancini for Baltimore’s only hit— and the Cleveland Indians defeated the Orioles 4-1 on Saturday.

Plutko, called up from Triple-A Columbus before the game, gave up the home run to Mancini with two outs in the fourth. The right-hander struck out four, walked two and was pulled after throwing 83 pitches.

Cleveland used three relievers to finish it. Oliver Perez struck out three of the four hitters he faced. Adam Cimber retired a batter in the eighth, but a fielding error by third baseman Jose Ramirez and a walk put two runners on.

Baltimore Orioles' Trey Mancini runs the bases after hitting a solo home run off Cleveland Indians starting pitcher Adam Plutko in the fourth inning of a baseball game, Saturday, May 18, 2019, in Cleveland. (AP Photo/Tony Dejak)
Baltimore Orioles’ Trey Mancini runs the bases after hitting a solo home run off Cleveland Indians starting pitcher Adam Plutko in the fourth inning of a baseball game, Saturday, May 18, 2019, in Cleveland. (AP Photo/Tony Dejak)

Brad Hand struck out Jonathan Villar to end the inning and worked the ninth for his 12th save in 12 chances.

Baltimore managed four baserunners on three walks and Ramirez’s error.

Jordan Luplow and Carlos Santana homered for Cleveland, extending Baltimore’s major-league-leading total of home runs allowed to 93.

Baltimore Orioles starting pitcher John Means delivers in the first inning of a baseball game against the Cleveland Indians, Saturday, May 18, 2019, in Cleveland. (AP Photo/Tony Dejak)
Baltimore Orioles starting pitcher John Means delivers in the first inning of a baseball game against the Cleveland Indians, Saturday, May 18, 2019, in Cleveland. (AP Photo/Tony Dejak)

Luplow hit a two-run homer in the fourth off John Means (5-4). The home run landed in the left field bleachers and followed Santana’s double for Cleveland’s first hit. Luplow, batting cleanup for the second time this season, has five home runs — all since May 9.

Santana hit a leadoff homer in the eighth off Miguel Castro.

The Indians were batting .223 at gametime and were held to three hits by Baltimore on Friday in a 5-1 loss. Cleveland rolled to a 14-7 win in the series opener Thursday and scored nine runs against the Chicago White Sox on Tuesday.

Cleveland Indians starting pitcher Adam Plutko delivers in the first inning of a baseball game against the Baltimore Orioles, Saturday, May 18, 2019, in Cleveland. (AP Photo/Tony Dejak)
Cleveland Indians starting pitcher Adam Plutko delivers in the first inning of a baseball game against the Baltimore Orioles, Saturday, May 18, 2019, in Cleveland. (AP Photo/Tony Dejak)

Means allowed three runs and five hits in five innings. The rookie left-hander won four of his previous five starts.

Plutko was 4-5 in 17 appearances with Cleveland last season. He was optioned to the minors at the end of spring training and didn’t pitch in April because of a strained forearm. He made two starts for Columbus before being called up to help Cleveland’s injury-depleted rotation.

Corey Kluber broke his right arm after being hit by a line drive in April and will be re-evaluated later this month. Mike Clevinger strained an upper back muscle in the second week of the season and could return in June.

El jugador de los Orioles de Baltimore, el dominicano Jonathan Villar, observa su jonrón de tres carreras ante el abridor de los Indios de Cleveland, el dominicano Jefry Rodríguez, en el tercer inning de un juego de béisbol, el viernes 17 de mayo de 2019, en Cleveland. (AP Foto/Tony Dejak)
El jugador de los Orioles de Baltimore, el dominicano Jonathan Villar, observa su jonrón de tres carreras ante el abridor de los Indios de Cleveland, el dominicano Jefry Rodríguez, en el tercer inning de un juego de béisbol, el viernes 17 de mayo de 2019, en Cleveland. (AP Foto/Tony Dejak)

Mancini drove a 1-0 pitch to the porch in left field for his team-leading 10th home run of the season and second in the series.

Oscar Mercado, called up from Columbus on Wednesday, doubled in the fifth for his first major league hit.

UP NEXT

Baltimore Orioles relief pitcher Mychal Givens, right, and catcher Austin Wynns celebrate after they defeated the Cleveland Indians in a baseball game, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)
Baltimore Orioles relief pitcher Mychal Givens, right, and catcher Austin Wynns celebrate after they defeated the Cleveland Indians in a baseball game, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)

Orioles: RHP Yefry Ramirez (0-1, 5.14 ERA) moves into the rotation after making his first three 2019 appearances in relief.

Indians: RHP Shane Bieber (2-2, 3.81 ERA) seeks his first home win of the year. He is 0-1 with a 4.43 ERA in four starts at Progressive Field.

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Chris Davis, derecha, pega un sencillo por los Orioles de Baltimore en el octavo inning del partido contra los Indios de Cleveland, el viernes 17 de mayo de 2019, en Cleveland. (AP Foto/Tony Dejak)
Chris Davis, derecha, pega un sencillo por los Orioles de Baltimore en el octavo inning del partido contra los Indios de Cleveland, el viernes 17 de mayo de 2019, en Cleveland. (AP Foto/Tony Dejak)
Baltimore Orioles' Trey Mancini hits a double in the eighth inning of a baseball game against the Cleveland Indians, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)
Baltimore Orioles’ Trey Mancini hits a double in the eighth inning of a baseball game against the Cleveland Indians, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)
Cleveland Indians' Jose Ramirez strikes out in the eighth inning of a baseball game against the Baltimore Orioles, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)
Cleveland Indians’ Jose Ramirez strikes out in the eighth inning of a baseball game against the Baltimore Orioles, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)
Baltimore Orioles' Stevie Wilkerson, right, and Renato Nunez celebrate after Wilkerson hit a solo home run off Cleveland Indians starting pitcher Jefry Rodriguez in the fourth inning of a baseball game, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)
Baltimore Orioles’ Stevie Wilkerson, right, and Renato Nunez celebrate after Wilkerson hit a solo home run off Cleveland Indians starting pitcher Jefry Rodriguez in the fourth inning of a baseball game, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)
Baltimore Orioles' Jonathan Villar is congratulated after hitting a three-run home run off Cleveland Indians starting pitcher Jefry Rodriguez in the third inning of a baseball game, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)
Baltimore Orioles’ Jonathan Villar is congratulated after hitting a three-run home run off Cleveland Indians starting pitcher Jefry Rodriguez in the third inning of a baseball game, Friday, May 17, 2019, in Cleveland. (AP Photo/Tony Dejak)
Cleveland Indians' Jake Bauers, right, watches his RBI-single off Baltimore Orioles starting pitcher Dylan Bundy as Orioles catcher Austin Wynns looks on in the second inning of a baseball game, Friday, May 17, 2019, in Cleveland. Jose Ramirez scored on the play. (AP Photo/Tony Dejak)
Cleveland Indians’ Jake Bauers, right, watches his RBI-single off Baltimore Orioles starting pitcher Dylan Bundy as Orioles catcher Austin Wynns looks on in the second inning of a baseball game, Friday, May 17, 2019, in Cleveland. Jose Ramirez scored on the play. (AP Photo/Tony Dejak)
Baltimore Orioles' Jonathan Villar watches his three-run home run off Cleveland Indians starting pitcher Jefry Rodriguez in the third inning of a baseball game, Friday, May 17, 2019, in Cleveland. Rio Ruiz and Austin Wynns also scored on the play. (AP Photo/Tony Dejak)
Baltimore Orioles’ Jonathan Villar watches his three-run home run off Cleveland Indians starting pitcher Jefry Rodriguez in the third inning of a baseball game, Friday, May 17, 2019, in Cleveland. Rio Ruiz and Austin Wynns also scored on the play. (AP Photo/Tony Dejak)