Lionel Messi has been left out of Barcelona’s starting lineup for Wednesday’s Copa del Rey semifinal match against Real Madrid.

Messi picked up an unspecified injury in his right leg during Saturday’s 2-2 draw with Valencia in the Spanish league.

He returned to training with the team on Tuesday and had been doubtful for the first leg of the semifinals against Madrid.

Little-used forward Malcolm was chosen by coach Ernesto Valverde to take Messi’s place.

Messi missed Barcelona’s 5-1 league rout of Madrid in October because of a broken right arm.

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